While in the ICU with a near-fatal case of pneumonia, Brett Walker was asked, "Do you have a family history of illness?" - a standard and deceptively simple question that for Walker, a professional historian, took on additional meaning and spurred him to investigate his family's medical past. In this deeply personal narrative, he constructs a history of his body to understand his diagnosis with a serious immunological disorder, weaving together his dying grandfather's sneaking a cigarette in a shed on the family's Montana farm, blood fractionation experiments in Europe during World War II, and 19th-century cholera outbreaks that ravaged small American towns as his ancestors were making their way west.

A Family History of Illness is a gritty historical memoir that examines the body's immune system and microbial composition as well as the biological and cultural origins of memory and history, offering a startling, fresh way to view the role of history in understanding our physical selves. In his own search, Walker soon realizes this broader scope is more valuable than a strictly medical family history. He finds that family legacies shape us both physically and symbolically, forming the root of our identity and values, and he urges us to renew our interest in the past or risk misunderstanding ourselves and the world around us.