In 1823, Tennessee historian John Haywood encapsulated a foundational sentiment among the white citizenry of Tennessee when he wrote of a "long continued course of aggression and sufferings" between whites and Native Americans. According to F. Evan Nooe, "aggression" and "sufferings" are broad categories that can be used to represent the framework of factors contributing to the coalescence of the white South.

Traditionally, the concept of coalescence is an anthropological model used to examine the transformation of Indigenous communities in the Eastern Woodlands. Applying this concept to white southerners, Nooe argues that through the experiences and selective memory of settlers in the antebellum South, white southerners incorporated their aggression against and suffering at the hands of the Indigenous peoples of the Southeast in the coalescence of a regional identity built upon the violent dispossession of the Native South.

Aggression and Sufferings prioritizes events in South Carolina, Florida, Tennessee, Georgia, and Alabama. Nooe considers how divergent systems of violence and justice between Native Americans and white settlers functioned in the region and examines the involved societies' conflicting standards on how to equitably resolve interpersonal violence.