Black Hands, White House documents and appraises the role enslaved women and men played in building the US, both its physical and its fiscal infrastructure. The book highlights the material commodities produced by enslaved communities during the Transatlantic Slave Trade. These commodities - namely tobacco, rice, sugar, and cotton, among others - enriched European and US economies; contributed to the material and monetary wealth of the nation's founding fathers, other early European immigrants, and their descendants; and bolstered the wealth of present-day companies founded during the American slave era. Critical to this study are also examples of enslaved laborers' role in building Thomas Jefferson's Monticello and George Washington's Mount Vernon. Subsequently, their labor also constructed the nation's capital city, Federal City (later renamed Washington, DC), its seats of governance - the White House and US Capitol - and other federal sites and memorials.

Given the enslaved community's contribution to the US, this work questions the absence of memorials on the National Mall that honor enslaved Black-bodied people. Harrison argues that such monuments are necessary to redress the nation's historical disregard of Black people and America's role in their forced migration, violent subjugation, and free labor.