It''s the dawn of the 22nd century, and the world has fallen apart. Decades of war and resource depletion have toppled governments. The ecosystem has collapsed. A new dust bowl sweeps the American West. The United States has become a nation of migrants - starving masses of nomads who seek out a living in desert wastelands and encampments outside government seed-distribution warehouses.

In this new world, there is a new power. Satori is more than just a corporation, she is an intelligent, living city that grew out of the ruins of Denver. Satori bioengineers both the climate-resistant seed that feeds a hungry nation, and her own post-human genetic Designers, Advocates, and Laborers. What remains of the United States government now exists solely to distribute Satori seed; a defeated American military doles out bar-coded, single-use Satori seed to the nation's starving citizens.

When one of Satori's Designers goes rogue, Agent Sienna Doss - ex-Army Ranger turned glorified bodyguard - is tasked by the government to bring her in: The government wants to use the Designer to break Satori's stranglehold on seed production and reassert themselves as the center of power. Sianna Doss's search for the Designer intersects with Brood and his younger brother Pollo - orphans scrapping by on the fringes of the wastelands. Pollo is abducted, because he is believed to suffer from Tet, a newly emergent disease, the victims of which are harvested by Satori. As events spin out of control, Brood and Sienna Doss find themselves at the heart of Satori, where an explosive climax promises to reshape the future of the world.