The most famous church in Jerusalem for nearly 2,000 years, the Church of the Holy Sepulchre, often called the Church of the Resurrection, was built in the era of St. Constantine, and the church as a structure has no history separable from the city of Jerusalem and its environs. It is venerated as being on the site where Jesus was crucified and buried, and naturally, making it a crucial pilgrimage site for Christians, and it is now the home of the Greek Orthodox Jerusalem Patriarchate. Moreover, it was the site of many important councils, some of which altered Christian history forever. In short, the Sepulchre was and is synonymous with Jerusalem, and it was essentially the nodal center of the city.

Naturally, the Church has had a turbulent history just as Jerusalem has. Under the Emperor Vespasian, Jerusalem was attacked and depopulated by Roman forces in 70 CE, and from 131-134, the Jewish revolt invited another Roman reprisal. Over and over again, Jerusalem has been decimated, sacked and razed. In 135, Hadrian rebuilt the city as a Roman outpost and called it "Aelia Capitolina" (Sicker, 2-3), and even the era of St. Constantine provided no respite from wars and dislocation. The Emperor Hadrian also removed Jews from the city upon its renovation (Sicker, 2-4).

In 313, Constantine the Great converted the Roman Empire and stopped the persecution of Christians, but the problems were far from over in Jerusalem. Jerusalem at the time was a center of pagan worship, with the emperor's main sanctuary being the temple of "Jupiter Capitolinus". The persecution had ended, but the hostility between Christians and non-Christians continued.