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You probably know the story of the late Wilma Mankiller, the first woman to serve as principal chief of the Cherokee Nation. You might not recognize the name of her husband, Charlie Soap, yet his role as a Native community organizer is no less significant. Last One Walking charts for the first time the life and work of this influential Cherokee.

ADHD may be the defining diagnosis of our time. According to the latest data, more than 10 percent of American children (that’s 7.1 million kids) have been diagnosed with ADHD. And the number of stimulant prescriptions for adults in their 30s has shot up nearly threefold since 2012. In recent years, this explosion in demand has combined with other factors to create a widespread stimulant shortage in the US. In the second installment of Backfired, cohosts Leon Neyfakh and Arielle Pardes look at the unintended consequences of the ADHD industry, and trace the surprising path that brought us here.

When two Stanford graduate students set out to create a new kind of cigarette that wouldn’t kill them, they didn’t foresee all the obstacles that lay ahead — or the powerful forces their invention would unleash. Nearly 10 years after the launch of the JUUL, Backfired: The Vaping Wars asks: Could e-cigarettes have been the solution to one of the world’s most pressing public health problems—or was this technology doomed to introduce a whole new generation to nicotine, and end up perpetuating an intractable addiction?