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"Anarchy is our aim.” A fire and murder at the Blackfriars’ Theological College catches the attention of Sherlock Holmes and Doctor Watson. “Barbarism is our belief.” Their investigation leads them into contact with the High Priestess and the strange but menacing disciples of, the Order of the Acolytes. “Chaos is our creed.”

Professor James Moriarty (Monaghan) is back for a gripping new adventure that finds him joining forces with his bitter rival, Sherlock Holmes (LaMarr). Moriarty tracks down the woman he loves but discovers that she is trapped in the web of a shadowy cabal of evil that’s growing stronger every day. To fight it, Moriarty must face Lady Milverton (Mirren), a ruthless mastermind whose blackmail poisons the highest levels of power. When he learns that his nemesis Sherlock Holmes is also in Milverton’s grip, the two must set their animosity aside to stop an escalating threat of world war.

The deadly dimensions over London have been sealed, and the monsters have departed. But word has come to Sherlock Holmes and Dr. Watson of a more terrifying creature still - the great Cthulhu has been sighted off the waters of Innsmouth, Massachusetts. Only Holmes can defeat him. And in the muddy village of Innsmouth, surrounded by villagers who are more sea-monster than human, Holmes meets again his nemesis, Moriarty, and yet greater foes: Amelia Scarcliffe and Maria Fitzgerald, harbingers of Dagon, who have called forth Cthulhu.

Dr Watson attends a hansom cab accident on Kensington High Street, in which a fellow general practitioner is seriously injured. Acting as a locum for his colleague, Watson is called to a mysterious death. Sherlock Holmes is asked for help, and discovers another similar death. Unravelling the mystery makes full use of Watson’s medical knowledge, but can our heroes prevent further deaths?